|專案日期||2019-03-04 ~ 2019-12-31|
|英文關鍵字||environmental pests, environmental agents, insecticides, efficacy test, Tessaratoma papillosa|
本計畫透過試驗106年已建立環境用藥藥效檢測方法、試驗規格設備及107年人用化學防蚊液藥效檢測方法檢討其適用性，及研議環境用藥產品新劑型及使用方法，建立及評估環境用藥藥效檢測方法技術規範，提供環境用藥申請、核發及管理之需要。 依據106年已建立之環境用藥藥效檢測方法及餌劑試驗裝置，進行各3種乳劑、超低容量劑、餌劑及凝膠餌劑之藥效檢測方法適用性之試驗及檢討，檢測結果乳劑以玻璃筒法、玻璃箱法及玻璃室法檢測可適用於飛行性昆蟲 (白線斑蚊、埃及斑蚊、熱帶家蚊、普通家蠅及果蠅) 及爬行性昆蟲 (德國蟑螂、美洲蟑螂、螞蟻及跳蚤) 之藥效檢測；乳劑另以殘效接觸法檢測結果，可適用於爬行性昆蟲 (德國蟑螂、美洲蟑螂、螞蟻、跳蚤及臭蟲) 之藥效檢測；3種超低容量劑以玻璃室法檢測可適用於飛行性昆蟲 (白線斑蚊、埃及斑蚊、熱帶家蚊及普通家蠅) 及爬行性昆蟲 (德國蟑螂及美洲蟑螂) 之藥效檢測；3種餌劑及凝膠餌劑以食餌試驗裝置檢測，可適用於爬行性昆蟲 (蟑螂及螞蟻) 之藥效檢測；利用107年人用化學防蚊液藥效檢測方法 (人體手臂測試法、動物測試法及人工血膜法) 檢測2種人用化學防蚊液 (有效成分：敵避7.0 % 及派卡瑞丁20.6%)，3種檢測方法檢測2種人用化學防蚊液，皆達完全保護效果 (吸血率 0.00 %)，可檢測產品標示之防治效果；另建立新劑型煙霧劑以玻璃室法、懸浮劑以W.H.O cone bioassay接觸法檢測飛行性昆蟲，以殘效接觸法檢測爬行性昆蟲，粉劑以接觸法檢測飛行性昆蟲 (普通家蠅) 及爬行性昆蟲 (德國蟑螂、美洲蟑螂及螞蟻)，建立3種新劑型之藥效檢測方法技術規範；及蒐集7筆荔枝椿象藥效檢測方法資料，研議其藥效檢測方法；本計畫實際完成進度100 %，符合期末報告100 % 要求。
This program established and evaluated the technical specifications for the efficacy testing of environmental drugs, environmental drug application, approval, release, and management by trying out the environmental drug efficacy test methods, specifications, and equipment established in 2017, reviewing the applicability of the human chemical mosquito repellent efficacy test methods in 2018, and researching new dosage forms and applications of environmental drug products. Based on the environmental drug efficacy test methods and bait formulation test equipment established in 2017, three emulsions of each drug, including ultra-low volume emulsions, bait formulations, and gel bait formulations, were tested and reviewed for applicability. The test results showed that the emulsions could be applied to flying insects (Aedes albopictus, Aedes aegypti, Culex quinquefasciatus, Musca domestica, and Drosophila melanogaster) and crawling insects (Blattella germanica, Periplaneta americana, ants and fleas) by the glass column method, the glass chamber method, and the glass room method. The emulsions could also be applied to crawling insects (Blattella germanica, Periplaneta americana, ants, fleas, and Cimex lectularius) by the residual contact method. Three ultra-low volume emulsions could be applied to flying insects (Aedes albopictus, Aedes aegypti, Culex quinquefasciatus, and Musca domestica) and crawling insects (Blattella germanica and Periplaneta americana) by the glass room method, and three bait formulations and gel bait formulations could be applied to crawling insects (cockroaches and ants) using bait devices. The human chemical mosquito repellent efficacy test methods (human hand test, animal test, and artificial vascular membrane) established in 2018 were used to test two human chemical mosquito repellents (DEET 7.0% and Picaridin 20.6%), and full protection effects (feeding rate: 0.00%) were achieved, indicating that the control effects specified on the products could be tested. In addition, the new smoke agents and suspending agents were tested by the glass room method and the WHO cone bioassay contact method, respectively, to learn the applicability to flying insects, and were tested by the residual contact method to learn the applicability to crawling insects. Powders were tested by the contact method to learn the applicability to flying insects (Musca domestica) and crawling insects (Blattella germanica, Periplaneta americana, and ants). In so doing, the technical specifications for the efficacy testing of three new dosage forms of drugs were established. Seven Tessaratoma papillosa efficacy test methods were collected for this research. The program was 100% completed and met the final report progress of 100%.